<p>Self-Assembling Peptide-Based Hydrogels in Angiogenesis</p>

Rational Molecular Design of Complementary Self-Assembling Peptide Hydrogels

Rational molecular design of self- assembling peptide-based materials that spontaneously form self-supporting hydrogels shows potential in many healthcare applications. Binary peptides based on complementary charged sequences are developed, and the use of biophysical analysis and cell-based studies highlights that the charged interactions can influence the properties of peptide materials and ul...

Functionalized d-form self-assembling peptide hydrogels for bone regeneration

Bone defects are very common in orthopedics, and there is great need to develop suitable bone grafts for transplantation in vivo. However, current bone grafts still encounter some limitations, including limited availability, immune rejection, poor osteoinduction and osteoconduction, poor biocompatibility and degradation properties, etc. Self-assembling peptide nanofiber scaffolds have emerged a...

Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells.

Our objective was to test the hypothesis that self-assembling peptide hydrogel scaffolds provide cues that enhance the chondrogenic differentiation of bone marrow stromal cells (BMSCs). BMSCs were encapsulated within two unique peptide hydrogel sequences, and chondrogenesis was compared with that in agarose hydrogels. BMSCs in all three hydrogels underwent transforming growth factor-beta1-media...

Understanding Gel Structural Properties to Control Macromolecule Mobility in Self Assembling Peptide Hydrogels

Western blot analysis of cells encapsulated in self-assembling peptide hydrogels.

Continuous optimization of in vitro analytical techniques is ever more important, especially given the development of new materials for tissue engineering studies. In particular, isolation of cellular components for downstream applications is often hindered by the presence of biomaterials, presenting a major obstacle in understanding how cell-matrix interactions influence cell behavior. Here, w...